Section Edited by Claudia Palena, PhD and Eric Tartour, MD, PhD
Basic and translational cancer immunology articles cover new tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response characterization and quantification, cancer and inflammation, preclinical models, pre-clinical evaluations of individual cancer therapeutics and combinations (chemotherapy, radiotherapy, immune checkpoint inhibitors and stimulators, and other antigen-specific immunotherapies). These should generally be focused on new findings in the context of the immune system and on correlations with measures of tumor reduction or growth. Studies leading to mechanistic understanding or novel development of agents and combination therapies are encouraged. Studies with in vivo experiments in more than one animal tumor model are preferred.
Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactionsRoeland Lameris, Adam Shahine, Myrthe Veth, Bart Westerman, Dale I Godfrey, David Lutje Hulsik, Patricia Brouwer, Jamie Rossjohn, Tanja D de Gruijl, Hans J van der Vliet
1 December 2023
Delayed vaccine-induced CD8 T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradicationTetje C van der Sluis, Floortje J van Haften, Suzanne van Duikeren, Iris N Pardieck, J Fréderique de Graaf, Ward Vleeshouwers, Koen van der Maaden, Cornelis J M Melief, Sjoerd H van der Burg, Ramon Arens
29 November 2023
TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinomaJiongjie Yu, Sunbin Ling, Jiachen Hong, Lincheng Zhang, Wei Zhou, Lu Yin, Shengjun Xu, Qingyang Que, Yongfeng Wu, Qifan Zhan, Jiaqi Bao, Nan Xu, Yuchen Liu, Kangchen Chen, Xuyong WeiSee the full list of authors
29 November 2023
MDSCs-derived GPR84 induces CD8 T-cell senescence via p53 activation to suppress the antitumor responseJinyan Liu, Jiayin Liu, Guohui Qin, Jiahui Li, Ziyi Fu, Jieyao Li, Miaomiao Li, Caijuan Guo, Ming Zhao, Zhen Zhang, Feng Li, Xuan Zhao, Liping Wang, Yi Zhang
28 November 2023
Single-cell RNA-sequencing atlas reveals an FABP1-dependent immunosuppressive environment in hepatocellular carcinomaWeiwei Tang, Guangshun Sun, Gu-Wei Ji, Tingting Feng, Qian Zhang, Hengsong Cao, Wenhao Wu, Xiaoyi Zhang, Chuan Liu, Hanyuan Liu, Tian Huang, Li Liu, Yongxiang Xia, Xuehao Wang
24 November 2023
Tumor cell-induced macrophage senescence plays a pivotal role in tumor initiation followed by stable growth in immunocompetent conditionHaruka Wada, Ryo Otsuka, Wilfred T V Germeraad, Tomoki Murata, Toru Kondo, Ken-ichiro Seino
13 November 2023
Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancerKelly Boelaars, Laura Goossens-Kruijssen, Di Wang, Charlotte M de Winde, Ernesto Rodriguez, Dimitri Lindijer, Babet Springer, Irene van der Haar Àvila, Aram de Haas, Laetitia Wehry, Louis Boon, Reina E Mebius, Nadine van Montfoort, Manfred Wuhrer, Joke M M den HaanSee the full list of authors
8 November 2023
Quantifying the impact of immunotherapy on RNA dynamics in cancerIeva Usaite, Dhruva Biswas, Krijn Dijkstra, Thomas BK Watkins, Oriol Pich, Clare Puttick, Mihaela Angelova, Krupa Thakkar, Crispin Hiley, Nicolai Birkbak, Marleen Kok, Simone Zaccaria, Yin Wu, Kevin Litchfield, Charles SwantonSee the full list of authors
1 November 2023
Cytosolic DNA accumulation promotes breast cancer immunogenicity via a STING-independent pathwayJing Zhang, Hui Dai, Lei Huo, Jared K Burks, Daniel J McGrail, Shiaw-Yih Lin
31 October 2023
Longitudinal evaluation of the biodistribution and cellular internalization of the bispecific CD3xTRP1 antibody in syngeneic mouse tumor modelsGerwin Gerhard Wemke Sandker, Jim Middelburg, Evienne Wilbrink, Janneke Molkenboer-Kuenen, Erik Aarntzen, Thorbald van Hall, Sandra Heskamp
29 October 2023