Section Edited by Claudia Palena, PhD, Walter Storkus, PhD and Eric Tartour, MD, PhD
Basic and translational cancer immunology articles cover new tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response characterization and quantification, cancer and inflammation, preclinical models, pre-clinical evaluations of individual cancer therapeutics and combinations (chemotherapy, radiotherapy, immune checkpoint inhibitors and stimulators, and other antigen-specific immunotherapies). These should generally be focused on new findings in the context of the immune system and on correlations with measures of tumor reduction or growth. Studies leading to mechanistic understanding or novel development of agents and combination therapies are encouraged. Studies with in vivo experiments in more than one animal tumor model are preferred.
Genome-wide CRISPR/Cas9 screen reveals factors that influence the susceptibility of tumor cells to NK cell-mediated killingSophie Guia, Aurore Fenis, Camille Baudesson De Chanville, Justine Galluso, Hakim Medjouel, Bertrand Escaliere, Angelika Modelska, Margaux Vienne, Noella Lopes, Amelie Pouchin, Benjamin Rossi, Laurent Gauthier, Sandrine Roulland, Eric Vivier, Emilie Narni-Mancinelli
31 March 2025
Orlistat facilitates immunotherapy via AKT-FOXO3a-FOXM1-mediated PD-L1 suppressionQingyun Tang, Jie Li, Lianhua Zhang, Shuo Zeng, Qiyu Bao, Weichao Hu, Lijiao He, Guiping Huang, Liting Wang, Yunyi Liu, Xiaoyan Zhao, Shiming Yang, Changjiang Hu
26 March 2025
Differential regulation of calcium-NFAT signaling pathway by Akt isoforms: unraveling effector dynamics and exhaustion of cytotoxic T lymphocytes in tumor microenvironmentWen-Ling Chen, Yong-Lin Chang, Su-Fang Lin, Ulrike Protzer, Masanori Isogawa, Hung-Chih Yang, Li-Rung Huang
26 March 2025
PLS-α-GalCer: a novel targeted glycolipid therapy for solid tumorsJulian Burks, Shweta Tiwary, David M Stevens, Sarah L Skoczen, Ruvanthi N Kularatne, Stephan T Stern, Jay A Berzofsky
22 March 2025
Depletion of tumor-derived CXCL5 improves T cell infiltration and anti-PD-1 therapy response in an obese model of pancreatic cancerRichard McKinnon Walsh, Joseph Ambrose, Jarrid L Jack, Austin E Eades, Bailey A Bye, Mariana Tannus Ruckert, Fanuel Messaggio, Appolinaire A Olou, Prabhakar Chalise, Dong Pei, Michael N VanSaun
22 March 2025
Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancerJulio C Tinoco, Harmony I Saunders, Lauryn Rose Werner, Xiaopeng Sun, Eilidh I Chowanec, Amanda Heard, Prabhakar Chalise, Jeffery M Vahrenkamp, Andrea E Wilson, Cong-Xiao Liu, Gangjun Lei, Junping Wei, Hugo Cros, Hisham Mohammed, Melissa TroesterSee the full list of authors
18 March 2025
Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR-proficient colorectal cancerJinlin Duan, Tao Chen, Qiwei Li, Yu Zhang, Ting Lu, Junyan Xue, Yang Sun, Ling Gao, Yonglong Zhang
13 March 2025
Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8 T cellsKayoung Shin, Min Park, Seoho Kim, Haejong Lee, Yuseong Lee, Jongil Kim, Suyoun Park, Jisoo Kim, Kyungwha Lee, Chong Woo Park, Ji-Hyun Kim, Eun-Jin Lee, Hyuckjun Mok, Sung-Man Oh, Sanghee LeeSee the full list of authors
13 March 2025
Fc-mediated immune stimulating, pro-inflammatory and antitumor effects of anti-HER2 IgE against HER2-expressing and trastuzumab-resistant tumorsMelanie Grandits, Lais C G F Palhares, Gabriel Osborn, Jitesh Chauhan, Katie Stoker, Heng Sheng Sow, Rebecca Adams, Alex J McCraw, Alicia Chenoweth, Sofia Vlasova, Jacobo López-Abente, Kristina M Ilieva, James Birtley, Sophia Tsoka, Elizabeth HardakerSee the full list of authors
12 March 2025
PD-1 promotes tumor evasion via deregulating CD8 T cell functionHaojing Zang, Tongfeng Liu, Xiaodong Wang, Shuwen Cheng, Xiaofeng Zhu, Chang Huang, Liqiang Duan, Xujie Zhao, Fang Guo, Xuetong Wang, Chang Zhang, Facai Yang, Yinmin Gu, Hongbo Hu, Shan Gao
6 March 2025