Section Edited by Claudia Palena, PhD and Eric Tartour, MD, PhD
Basic and translational cancer immunology articles cover new tumor antigens, innate and adaptive anti-tumor immune mechanisms, immune regulation, immune response characterization and quantification, cancer and inflammation, preclinical models, pre-clinical evaluations of individual cancer therapeutics and combinations (chemotherapy, radiotherapy, immune checkpoint inhibitors and stimulators, and other antigen-specific immunotherapies). These should generally be focused on new findings in the context of the immune system and on correlations with measures of tumor reduction or growth. Studies leading to mechanistic understanding or novel development of agents and combination therapies are encouraged. Studies with in vivo experiments in more than one animal tumor model are preferred.
HDAC inhibitor SAHA enhances antitumor immunity via the HDAC1/JAK1/FGL1 axis in lung adenocarcinomaTingting Xu, Yuan Fang, Yunru Gu, Duo Xu, Tong Hu, Tao Yu, Yang-Yue Xu, Hao-Yang Shen, Pei Ma, Yongqian Shu
9 October 2024
Novel H-2D-restricted CD8 epitope derived from mouse MAGE-type antigen P1A mediates antitumor immunity in C57BL/6 miceJames McAuliffe, Silvia Panetti, Emily Steffke, Amanda Wicki, Vinnycius Pereira-Almeida, Laurine Noblecourt, Yushu Hu, Shi Yu William Guo, Julie Lesenfants, Ramiro Andrei Ramirez-Valdez, Vineethkrishna Chandrasekar, Maryam Ahmad, Vincent Stroobant, Nathalie Vigneron, Benoit J Van den EyndeSee the full list of authors
8 October 2024
Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor controlCarlos R Detrés Román, Megan M Erwin, Michael W Rudloff, Frank Revetta, Kristen A Murray, Natalie R Favret, Jessica J Roetman, Joseph T Roland, Mary K Washington, Mary Philip
3 October 2024
Novel bispecific antibody-drug conjugate targeting PD-L1 and B7-H3 enhances antitumor efficacy and promotes immune-mediated antitumor responsesYijun Dong, Zongliang Zhang, Siyuan Luan, Meijun Zheng, Zeng Wang, Yongdong Chen, Xiaoting Chen, Aiping Tong, Hui Yang
2 October 2024
Inhibition of the NF-κB/HIF-1α signaling pathway in colorectal cancer by tyrosol: a gut microbiota-derived metaboliteJian Guo, Fanqi Meng, Ruixue Hu, Lei Chen, Jiang Chang, Ke Zhao, Honglin Ren, Zengshan Liu, Pan Hu, Guangyi Wang, Jiandong Tai
28 September 2024
Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockadeNicola Principe, Amber-Lee Phung, Kofi L P Stevens, Omar Elaskalani, Ben Wylie, Caitlin M Tilsed, Fezaan Sheikh, M Lizeth Orozco Morales, Joel Kidman, Elly Marcq, Scott A Fisher, Anna K Nowak, Alison M McDonnell, W Joost Lesterhuis, Jonathan Chee
28 September 2024
Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancersKhaldoun Gharzeddine, Cristina Gonzalez Prieto, Marie Malier, Clara Hennot, Renata Grespan, Yoshiki Yamaryo-Botté, Cyrille Y Botté, Fabienne Thomas, Marie-Hélène Laverriere, Edouard Girard, Gael Roth, Arnaud Millet
24 September 2024
Spatial colocalization and combined survival benefit of natural killer and CD8 T cells despite profound MHC class I loss in non-small cell lung cancerRemziye E Wessel, Nardin Ageeb, Joseph M Obeid, Ileana S Mauldin, Kate A Goundry, Gabriel F Hanson, Mahdin Hossain, Chad Lehman, Ryan D Gentzler, Nolan A Wages, Craig L Slingluff, Jr, Timothy N J Bullock, Sepideh Dolatshahi, Michael G Brown
18 September 2024
S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signalingFeyza Gül Özbay Kurt, Beatrice-Ana Cicortas, Bianca M Balzasch, Carolina De la Torre, Volker Ast, Ece Tavukcuoglu, Cagla Ak, Sebastian A Wohlfeil, Adelheid Cerwenka, Jochen Utikal, Viktor Umansky
11 September 2024
Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathwayZelin Hou, Fengchun Lu, Jiajing Lin, Yuwei Wu, Linjin Chen, Haizong Fang, Linlin Chen, Shihan Zhang, Heguang Huang, Yu Pan
4 September 2024