Section Edited by Jason J. Luke, MD, FACP and Douglas G. McNeel, MD, PhD
Clinical cancer immunotherapy articles cover clinical trials and mechanistic studies using blood or tissue specimens from patients treated with immunotherapy agents (translational subset). Clinical trial articles are prospective studies including first-in-human clinical trials using agents with novel mechanisms of action, or phase II/III clinical studies, that show clinical outcome and/or translational immune investigations. Small, single institution-based trials and retrospective reports are discouraged. Reports purely for biomarker development are discouraged, and should be submitted to the Immunotherapy Biomarkers section. Clinical trial manuscripts must be accompanied by a protocol and clinical trial registration number. Large phase II/III trials with robust clinical outcomes, or smaller trials accompanied by mechanistic, correlative studies, are encouraged.
Impact of tumor localization on antitumor immunity with conditionally activated CTLA-4 blockadeMarcel Arias-Badia, Chien-Chun Steven Pai, Yee May Lwin, PeiXi Chen, Aahir Srinath, Miho Tanaka, Emily Musser, Andrew Goodearl, Jacob V Gorman, Wendy Ritacco, Lawrence Fong
2 April 2025
Phase I study on neoadjuvant combination immunotherapy with mogamulizumab and nivolumab for solid tumorsKoichi Jinushi, Takuro Saito, Koji Kurose, Susumu Suzuki, Takashi Kojima, Taishi Takahara, Tomoki Makino, Tetsuya Ogawa, Hiroyoshi Nishikawa, Kazuhiro Kakimi, Shinsuke Iida, Jun Nakajima, Yuichiro Doki, Mikio Oka, Ryuzo UedaSee the full list of authors
2 April 2025
Systemic immunomodulation by irreversible electroporation versus stereotactic ablative body radiotherapy in locally advanced pancreatic cancer: the CROSSFIRE trialBart Geboers, Florentine Timmer, Danielle Vos, Hester Scheffer, Joyce Bakker, Alette Ruarus, Laurien Vroomen, Anita Stam, Sinéad Lougheed, Evelien Schouten, Robbert Puijk, Petrousjka van den Tol, Frank Lagerwaard, Jan de Vries, Anna BruynzeelSee the full list of authors
26 March 2025
mTOR inhibition modulates vaccine-induced immune responses to generate memory T cells in patients with solid tumorsHenry G Withers, Junko Matsuzaki, Mark Long, Spencer R Rosario, Thinle Chodon, Takemasa Tsuji, Richard Koya, Li Yan, Jianming Wang, Tibor Keler, Shashikant B Lele, Emese Zsiros, Amit Lugade, Alan Hutson, Stephanie BlankSee the full list of authors
25 March 2025
Cardiac MRI study of adverse events in patients treated with immune checkpoint inhibitors: a prospective cohort study of cardiac adverse eventsAgnese Losurdo, Cristina Panico, Chiara Catalano, Simone Serio, Laura Giordano, Lorenzo Monti, Federica Catapano, Stefano Figliozzi, Carla D’Andrea, Angelo Dipasquale, Pasquale Persico, Antonio Di Muzio, Marco Cremonesi, Alessandro Marchese, Maria Chiara TronconiSee the full list of authors
18 March 2025
Nivolumab adjuvant to chemo-radiation in localized muscle-invasive urothelial cancer: primary analysis of a multicenter, single-arm, phase II, investigator-initiated trial (NEXT)Gliceida M. Galarza Fortuna, Daniel Grass, Benjamin L Maughan, Rohit K Jain, Christopher Dechet, Julia Beck, Ekke Schuetz, Alejandro Sanchez, Brock O’Neil, Michael Poch, Roger Li, Shane Lloyd, Jonathan Tward, Tenzin Phunrab, Josiah Lyn HawksSee the full list of authors
18 March 2025
New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesotheliomaNoémie Joalland, Agnès Quéméner, Sophie Deshayes, Romain Humeau, Mike Maillasson, Héloïse LeBihan, Apolline Salama, Judith Fresquet, Séverine Remy, Erwan Mortier, Christophe Blanquart, Carole Guillonneau, Ignacio Anegon
17 March 2025
Leveraging T cell co-stimulation for enhanced therapeutic efficacy of trispecific antibodies targeting prostate cancerYanping Sun, Linling Zhou, Xinyu Gu, Jiaqi Zhao, Jie Bi, Liqiang Pan
13 March 2025
Phase 2 study of neoadjuvant durvalumab plus docetaxel, oxaliplatin, and S-1 with surgery and adjuvant durvalumab plus S-1 for resectable locally advanced gastric cancerYoon-Koo Kang, Hyung-Don Kim, Hyungwoo Cho, Young Soo Park, Jong Seok Lee, Min-Hee Ryu
13 March 2025
Cell-intrinsic PD-L1 signaling drives immunosuppression by myeloid-derived suppressor cells through IL-6/Jak/Stat3 in PD-L1-high lung cancerHyein Jeong, Jaemoon Koh, Sehui Kim, Jeemin Yim, Seung Geun Song, Hanbyeol Kim, Yingying Li, Soo Hyun Lee, Yeon Kyu Chung, Hongsoon Kim, Chul-Hwan Lee, Hye Young Kim, Bhumsuk Keam, Se-Hoon Lee, Doo Hyun ChungSee the full list of authors
6 March 2025